Dissolution enhancement of poorly soluble drug by solvent evaporation method using hydrophilic polymer: a solid dispersion technique

Studies on dissolution enhancement of prednisolone, a poorly water-soluble drug by solid dispersion technique.

INTRODUCTION Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. METHODS Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose a...

Enhancement of dissolution profile for oral delivery of Fexofenadine Hydrochloride by solid dispersion (solvent evaporation) technique

The objective of present work is to investigate the enhancement of dissolution profile for oral delivery of Fexofenadine Hydrochloride (FH) through solid dispersion (SD) technique by the method of solvent evaporation. The SD was prepared by using ethanol as a solvent. Tablets were formulated containing solid dispersion of FH and compared with tablets of same formula without solid dispersion of ...

dissolution enhancement of glibenclamide by solid dispersion: solvent evaporation versus a supercritical fluid-based solvent -antisolvent technique

glibenclamide (glib) is a poorly soluble drug with formulation-dependent bioavailability. therefore, we attempted in this study to improve glib dissolution rate by preparing drug solid dispersions by solvent evaporation (se) and supercritical fluid solvent-antisolvent techniques (scf-sas). a d-optimal mixture design was used to investigate the effects of different ratios of hpmc e5 (50-100%), p...

Dissolution enhancement of glibenclamide by solid dispersion: solvent evaporation versus a supercritical fluid-based solvent -antisolvent technique

Glibenclamide (GLIB) is a poorly soluble drug with formulation-dependent bioavailability. Therefore, we attempted in this study to improve GLIB dissolution rate by preparing drug solid dispersions by solvent evaporation (SE) and supercritical fluid solvent-antisolvent techniques (SCF-SAS). A D-optimal mixture design was used to investigate the effects of different ratios of HPMCE5 (50-100%), PE...

dissolution enhancement of glybenclamide by solid dispersion technique